DNA Sequencing (Next-Generation Sequencing)
Gene technology is defined as the term which includes a range of activities concerned with understanding of gene expression, advantages of natural genetic variation, modifying genes and transferring genes to new hosts. The Journal is successfully running in the 9th Volume which covers a wide variety of specialties including Gene Engineering, Gene Expression, Gene Mutation, Next-Generation Sequencing for reporting on the latest advances in both the clinical and laboratory investigation of Genes.
DNA sequencing is the process of determining the sequence of nucleic acids-the order of nucleotides in DNA. This requires any process or technology used to evaluate the four bases in order: adenine, guanine, cytosine, and thymine. The advent of rapid DNA sequencing methods has speeded up biological and medical research and discovery considerably.
Next-generation sequencing (NGS) is also known as high-throughput sequencing it is term used to describe a number of different modern sequencing technologies including Illumina (Solexa) sequencing, Whole genome sequencing, Targeted sequencing, Amplicon sequencing, exome sequencing, De novo sequencing , Transcriptomics etc. These recent technologies allow us to sequence DNA and RNA much more quickly and cheaply than the previously used Sanger sequencing, and as such have revolutionised the study of genomics and molecular biology.
DNA is a molecule composed of two chains that coil around each other to form a double helix containing genetic instructions for the development, functioning, growth and reproduction of all known organisms and numerous viruses. Nucleic acids are DNA and ribonucleic acid (RNA), alongside proteins, lipids and complexes.
DNA strands are also known as polynucleotides, as they consist of simpler monomeric units called nucleotides, Each nucleotide consists of one of four nucleobases containing nitrogen (cytosine[C ], guanine[G ], adenine[A ] or thymine[T ]), a sugar called deoxyribose, and a phosphate component. In a chain, the nucleotides are joined by covalent bonds between the sugars.
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